SrasV1, Main, Exploration, bibRecord, 002510

Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans.

Identifieur interne : 002510 ( Main/Exploration ); précédent : 002509; suivant : 002511

Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans.

Auteurs : Junfa Yuan [République populaire de Chine] ; Chung-Chau Hon ; Yan Li ; Dingming Wang ; Gelin Xu ; Huajun Zhang ; Peng Zhou ; Leo L M. Poon ; Tommy Tsan-Yuk Lam ; Frederick Chi-Ching Leung ; Zhengli Shi

Source :

The Journal of general virology [ 1465-2099 ] ; 2010.

RBID : pubmed:20016037

Descripteurs français

KwdFr :
- Animaux, Chiroptera (virologie), Cytochromes b (génétique), Données de séquences moléculaires, Humains, Phylogénie, Protéines virales non structurales (génétique), RNA replicase (génétique), Recombinaison génétique, Séquence nucléotidique, Virus du SRAS (), Virus du SRAS (génétique).
MESH :
- génétique : Cytochromes b, Protéines virales non structurales, RNA replicase, Virus du SRAS.
- virologie : Chiroptera.
- Animaux, Données de séquences moléculaires, Humains, Phylogénie, Recombinaison génétique, Séquence nucléotidique, Virus du SRAS.

English descriptors

KwdEn :
- Animals, Base Sequence, Chiroptera (virology), Cytochromes b (genetics), Humans, Molecular Sequence Data, Phylogeny, RNA Replicase (genetics), Recombination, Genetic, SARS Virus (classification), SARS Virus (genetics), Viral Nonstructural Proteins (genetics).
MESH :
- chemical , genetics : Cytochromes b, RNA Replicase, Viral Nonstructural Proteins.
- classification : SARS Virus.
- genetics : SARS Virus.
- virology : Chiroptera.
- Animals, Base Sequence, Humans, Molecular Sequence Data, Phylogeny, Recombination, Genetic.

Abstract

The Chinese rufous horseshoe bat (Rhinolophus sinicus) has been suggested to carry the direct ancestor of severe acute respiratory syndrome (SARS) coronavirus (SCoV), and the diversity of SARS-like CoVs (SLCoV) within this Rhinolophus species is therefore worth investigating. Here, we demonstrate the remarkable diversity of SLCoVs in R. sinicus and identify a strain with the same pattern of phylogenetic incongruence (i.e. an indication of recombination) as reported previously in another SLCoV strain. Moreover, this strain possesses a distinctive 579 nt deletion in the nsp3 region that was also found in a human SCoV from the late-phase epidemic. Phylogenetic analysis of the Orf1 region suggested that the human SCoVs are phylogenetically closer to SLCoVs in R. sinicus than to SLCoVs in other Rhinolophus species. These findings reveal a closer evolutionary linkage between SCoV in humans and SLCoVs in R. sinicus, defining the scope of surveillance to search for the direct ancestor of human SCoVs.

DOI: 10.1099/vir.0.016378-0
PubMed: 20016037

Affiliations:

Le document en format XML

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<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>RNA Replicase (genetics)</term>
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<term>Protéines virales non structurales (génétique)</term>
<term>RNA replicase (génétique)</term>
<term>Recombinaison génétique</term>
<term>Séquence nucléotidique</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (génétique)</term>
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<front><div type="abstract" xml:lang="en">The Chinese rufous horseshoe bat (Rhinolophus sinicus) has been suggested to carry the direct ancestor of severe acute respiratory syndrome (SARS) coronavirus (SCoV), and the diversity of SARS-like CoVs (SLCoV) within this Rhinolophus species is therefore worth investigating. Here, we demonstrate the remarkable diversity of SLCoVs in R. sinicus and identify a strain with the same pattern of phylogenetic incongruence (i.e. an indication of recombination) as reported previously in another SLCoV strain. Moreover, this strain possesses a distinctive 579 nt deletion in the nsp3 region that was also found in a human SCoV from the late-phase epidemic. Phylogenetic analysis of the Orf1 region suggested that the human SCoVs are phylogenetically closer to SLCoVs in R. sinicus than to SLCoVs in other Rhinolophus species. These findings reveal a closer evolutionary linkage between SCoV in humans and SLCoVs in R. sinicus, defining the scope of surveillance to search for the direct ancestor of human SCoVs.</div>
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Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans.

Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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